An overview of ozanimod as a therapeutic option 窍门和秘籍来赢得更多 Expert Option 窍门和秘籍来赢得更多 Expert Option for adults with moderate-to-severe active ulcerative colitis
Introduction: Ulcerative colitis (UC) is a chronic inflammatory condition of the gastrointestinal 窍门和秘籍来赢得更多 Expert Option tract involving a dysregulated immune response. Sphingosine-1-phosphate (S1P) is involved 窍门和秘籍来赢得更多 Expert Option in immune cell regulation. S1P-receptor modulators, such as ozanimod, inhibit 窍门和秘籍来赢得更多 Expert Option lymphocyte migration and have therapeutic potential in UC.
Areas covered: Ozanimod is the first S1P-receptor modulator approved for 窍门和秘籍来赢得更多 Expert Option 窍门和秘籍来赢得更多 Expert Option the treatment of UC. It acts as a functional antagonist, 窍门和秘籍来赢得更多 Expert Option causing internalization of S1P receptors on T-cells. Lymphocyte egress from 窍门和秘籍来赢得更多 Expert Option lymph nodes is inhibited, and migration to sites of active 窍门和秘籍来赢得更多 Expert Option inflammation is curtailed. There are several S1P-receptor subtypes, present in various organs, which inform understanding of ozanimod's side-effect profile 窍门和秘籍来赢得更多 Expert Option including bradycardia and macular edema. In this review, the authors discuss the mechanism of action, pharmacokinetics, clinical efficacy, and safety profile of ozanimod in the treatment of patients with moderate-to-severe 窍门和秘籍来赢得更多 Expert Option UC.
Expert opinion: The S1P-receptor modulator ozanimod is an oral small molecule with a rapid onset of action 窍门和秘籍来赢得更多 Expert Option and a novel therapeutic mechanism in the treatment of UC. It is an effective treatment both in bio-naïve and bio-exposed patients. Although the safety profile of ozanimod looks favorable, more long-term data are needed. Further studies are required to compare ozanimod to currently available therapies to best define its positioning in UC treatment algorithms.
Keywords: Inflammatory bowel disease; ozanimod; small molecules; sphingosine-1-phosphate receptor modulators; ulcerative colitis.
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Argollo M, Furfaro F, Gilardi D, Roda G, Allocca M, Peyrin-Biroulet L, Danese S. Argollo M, et al. Expert Opin Biol Ther. 2020 Apr;20(4):413-420. doi: 10.1080/14712598.2020.1732919. Epub 窍门和秘籍来赢得更多 Expert Option 窍门和秘籍来赢得更多 Expert Option 2020 Feb 25. Expert Opin Biol Ther. 2020. PMID: 32093531 窍门和秘籍来赢得更多 Expert Option Review.
Sandborn WJ, Feagan BG, Wolf DC, D'Haens G, Vermeire S, Hanauer SB, Ghosh S, Smith H, Cravets M, Frohna PA, Aranda R, Gujrathi S, Olson A; TOUCHSTONE Study 窍门和秘籍来赢得更多 Expert Option Group. Sandborn WJ, et al. N Engl J Med. 2016 May 5;374(18):1754-62. doi: 10.1056/NEJMoa1513248. N Engl J Med. 2016. PMID: 27144850 Clinical Trial.
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