如何设置社交交易 Expert Option

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Clonezilla

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Pharmacotherapeutic Options for Chronic Refractory Cough

Introduction: Chronic 如何设置社交交易 Expert Option refractory cough (CRC) is more than a persistent cough, but can cause serious impairment to quality of life. Through remarkable advances in our understanding of the neurobiology of cough, there is realization that CRC can be controlled by novel drugs that target cough reflex pathways.

Areas covered: The authors present an overview of the clinical trials of antitussives for CRC, and ongoing clinical trials of novel drugs. They discuss the potential strengths and limitations of each medication, as well as knowledge gaps and uncertainties that should be addressed by future trials of putative CRC treatments.

Expert opinion: Currently-available antitussive drugs (i.e., opioids and gabapentin) are centrally-acting drugs primarily used for pain and neuropathic conditions; they were not designed for cough and have limitations with respect to efficacy and safety. Due to the success of gefapixant, a first-in-class P2X3 antagonist, early phase trials with different therapeutic targets in the cough reflex pathways have been conducted; these are expected to control cough hypersensitivity, while preserving protective cough reflex. However, the reported effects of antitussive drugs depend on the clinical context, cough outcome measures or cough characteristics. Further biomarkers are needed to accurately predict responders to different antitussive drugs.

Keywords: Chronic cough; 如何设置社交交易 Expert Option antitussives; cough hypersensitivity; refractory cough.

Cited by

Smith JA, Birring SS, Dicpinigaitis PV, McGarvey LP, Morice AH, Pavord ID, Satia I, Green S, Iskold B, La Rosa C, Li Q, Martin Nguyen A, Schelfhout J, Muccino D. Smith JA, et al. Lung. 2022 Aug;200(4):423-429. doi: 10.1007/s00408-022-00553-y. Epub 2022 Jul 27. Lung. 2022. PMID: 35895098 Free PMC article. Clinical Trial.

Gui P, Wang L, Guo L, Wu C, Zhang B, Chen C, Xie Y. Gui P, et al. Respir Res. 2022 Apr 21;23(1):99. doi: 10.1186/s12931-022-02020-x. Respir Res. 2022. PMID: 35449062 Free PMC article. Clinical Trial.

Song WJ, Hui CKM, Hull JH, Birring SS, McGarvey L, Mazzone SB, Chung KF. Song WJ, et al. Lancet Respir Med. 2021 May;9(5):533-544. doi: 10.1016/S2213-2600(21)00125-9. Epub 2021 Apr 12. Lancet Respir Med. 2021. PMID: 33857435 Free PMC article. Review.

Chen Z, Chen P, Wu H, Shi R, Su W, Wang Y, Li P. Chen Z, et al. Biomolecules. 2020 Dec 8;10(12):1644. doi: 10.3390/biom10121644. Biomolecules. 2020. PMID: 33302350 Free PMC article. Review.

Singh N, Driessen AK, McGovern AE, Moe AAK, Farrell MJ, Mazzone SB. Singh N, et 如何设置社交交易 Expert Option al. J Thorac Dis. 2020 Sep;12(9):5179-5193. doi: 10.21037/jtd-2020-icc-007. J Thorac Dis. 2020. PMID: 33145095 Free PMC article. Review.

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